IBT 13131
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide
CAS: 313553-47-8
Molecular Formula: C18H16N2OS
IBT 13131 - Names and Identifiers
IBT 13131 - Physico-chemical Properties
| Molecular Formula | C18H16N2OS |
| Molar Mass | 308.4 |
| Density | 1.239±0.06 g/cm3 (20 ºC 760 Torr) |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | INH1 reduces the Association of Hec1 with kinetochore and reduces overall Nek2 protein levels in cells. INH1 effectively inhibited the proliferation of human breast cancer cells with a GI50 of 10-21 μm. In addition, INH1 can also activate the cell killing activity by impairing the Hec1/Nek2 pathway regulated by the spindle monitoring point. INH1 reduces the Association of Hec1 with kinetochore and reduces overall Nek2 protein levels in cells. INH1 effectively inhibited the proliferation of human breast cancer cells with a GI50 of 10-21 μm. In addition, INH1 can also activate the cell killing activity by impairing the Hec1/Nek2 pathway regulated by the spindle monitoring point. |
| In vivo study | INH1 (100 mg/kg, I. P.) inhibited breast tumor growth in MDA-MB-468 human breast cancer xenografted mice. INH1 (100 mg/kg, I. P.) inhibited breast tumor growth in MDA-MB-468 human breast cancer xenografted mice. |
IBT 13131 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.243 ml | 16.213 ml | 32.425 ml |
| 5 mM | 0.649 ml | 3.243 ml | 6.485 ml |
| 10 mM | 0.324 ml | 1.621 ml | 3.243 ml |
| 5 mM | 0.065 ml | 0.324 ml | 0.649 ml |
Last Update：2024-01-02 23:10:35
IBT 13131 - Reference Information
| biological activity | INH1 is a Hec1 inhibitor of cell permeability that specifically disrupts the Hec1/Nek2 interaction. INH1 (IBT 13131) is a Hec1 inhibitor of cell permeability that specifically disrupts the Hec1/Nek2 interaction. |
| In vitro studies | INH1 reduces the Association of Hec1 with kinetochore and reduces overall Nek2 protein levels in cells. INH1 effectively inhibited the proliferation of human breast cancer cells with a GI50 of 10-21 μm. In addition, INH1 can also activate the cell killing activity by impairing the Hec1/Nek2 pathway regulated by the spindle monitoring point. INH1 reduces the Association of Hec1 with kinetochore and reduces overall Nek2 protein levels in cells. INH1 effectively inhibited the proliferation of human breast cancer cells with a GI50 of 10-21 μm. In addition, INH1 can also activate the cell killing activity by impairing the Hec1/Nek2 pathway regulated by the spindle monitoring point. |
| in vivo study | MDA-MB-468 human breast cancer xenograft mice, INH1 (100 mg/kg, I. P.) inhibits breast tumor growth. INH1 (100 mg/kg, I. P.) inhibited breast tumor growth in MDA-MB-468 human breast cancer xenografted mice. |
| Target | TargetValue Hec1 |
| Target | Value |
Last Update：2024-04-09 20:02:46
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